微生物によるニトロサミンの分解-I : 酵素分解

概要

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In order to investigate the microbial degradation of nitrosamines, the degrading activity of three strains of non-pathogenic microorganisms, i. e., Rhizopus oryzae, Streptococcus cremoris, and Sccaromyces rouxii was examined. These microorganism, were active in degrading NDMA, NDEA, NDPA, NPYR, and NPIP, NDPA bejng degraded more rapidly than the other nitrosamines. Rhizopus oryzae degraded 804 of NDPA, 40% of NPIP, 25% of NDEA, 20% of NPYR, and 10% of NDMA (precentages of amounts added to the medium). Streptococcus cremoris and Saccharomyces rouxii degraded 70% and 50% of NDPA respectively; the other nitrosamines were degraded to a smaller extent. NDPA was also degraded faster in the suspensions of cells of these three strains precultured in the medium containing the nitrosamine than in the control cultures, i. e., the suspensions of cells harvested from the medium which did not contain NDPA. The cell-free extract of Rhizopus oryzae grown in the medium containing either NDMA or NDPA was active in degrading these two nitrosamines. These results suggest that the degradation of nitrosamines is conducted by an inducible enzyme.
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