Distribution and orientation of genes in the genome of Pyrococcus OT3

概要

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Novel characteristics of genes identified in the genome of a hyper-thermophilic archaebacterium, Pyrococcus sp. OT3, are described by correlating the 1.74M bases in the circular genome to the 12 hours in a clock. From 0:00 to 7:00 the bases are used to code more for the genes whose transcription takes place in the clockwise direction, while from 7:00 to 12:00 to code more for the genes whose transcription takes place in the anti-clockwise direction. Genes that are closely related to known eubacterial genes distribute equally through the genome without showing any strong position-preference. In contrast, genes that are closely related to known eukaryotic genes have tendency to cluster from 1:30 to 3:30. On the basis of these findings a possible link between transcription and replication and the origin of archaebacterial genomes are discussed.
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