Feast/famine regulatory proteins of a multiple drug resistant, Pseudomonas aeruginosa

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The eubacterium Pseudomonas aeruginosa is an opportunistic pathogen, and at the same, possesses a high ability to resist antibiotics and disinfectants. Using the genomic sequence of its standard strain PAO1, determined by another group, genes coding feast/famine regulatory proteins (FFRPs) have been identified. In general, FFRPs regulate transcription of genes, thereby controlling metabolism, growth and environmental adaptation of bacteria, and thus they are obvious targets when designing drugs in order to irradicate P. aeruginosa. In the light of findings on FFRPs of other bacteria, amino acid residues of FFRPs of P. aeruginosa that are likely to be involved in DNA recognition or interaction with natural ligands have been identified. One of the FFRPs, Pa5977610, has been identified as orthologous to an E. coli FFRP, the leucine-responsive regulatory protein (Lrp). Another FFRP, Pa2220251, resembles another E. coli FFRP, YbaO, to a lesser extent. No FFRP of P. aeruginosa is orthologous to the third E. coli FFRP, AsnC. These differences among P. aeruginosa FFRPs can be used for selecting appropriate target proteins, thereby minimizing potential interaction of drugs to be developed with the human symbiont E. coli.(Communicated by Masanori OTSUKA, M. J. A., Oct. 14, 2003)
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