Mutations of Glucocorticoid Responsive Element of HBV DNA.
スポンサーリンク
概要
- 論文の詳細を見る
The mutation of glucocorticoid responsive element (GRE) of HBV DNA obtained from a patient with chronic hepatitis B was evaluated. This patient showed fatal course by glucocorticoid administration. The HBV DNA from this patient (GRE-M) and two patients with HBeAg positive chronic hepatitis B (GRE-W1, 2), whose HBV DNA have few mutations, were examined. The 212 bp region from nt.274 to nt.485 (GRE region) was amplified by PCR and the nucleotide sequence was determined. A base mismatched sequence of the latter half of the GRE consensus sequence was confirmed at nt.296-301 (G1), nt.347-352 (G2), nt.359-364 (G3), and nt.473-478 (G4). Also one base mismatched sequence of the AP-1 response element was detected at nt.331-337 (A1). The nucleotide substitutions in GRE-M generate three putative loop formation sites, four bases in length, from nt.22 to nt.31 (L1), nt.35 to nt.42 (L2), and nt.74 to nt.83 (L3). The L1 was located just upstream of the G1. The L2 was located between the Al and the G2. These mutations follwed by three dimentional form change may affect the responses to glucocorticoid.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
SASAKI Masaru
The Second Department of Medicine, Kurume University School of Medicine
-
SUZUKI Hiroshi
The Second Department of Medicine, Kurume University School of Medicine
-
Tanikawa Kyuichi
The Second Department Of Internal Medicine Kurume University School Of Medicine
-
Akiyoshi Fuyuhiko
The Second Department Of Medicine Kurume University School Of Medicine
-
SATA Michio
the Second Department of Internal Medicine, Kurume University of Medicine
-
NOGUCHI SEIJI
The Second Department of Medicine, Kurume University School of Medicine
-
MURASHIMA SHIROU
The Second Department of Medicine, Kurume University School of Medicine
関連論文
- Granulocytapheresis (GCAP) for severe alcoholic hepatitis-A preliminary report
- Liposome-mediated gene transfer of K1-5 suppresses tumor development and improves the prognosis of hepatocellular carcinoma in mice
- Systemic Sclerosis Associated with Diabetes Insipidus
- Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene
- Interferon-γ brings additive anti-viral environment when combined with interferon-α in patients with chronic hepatitis C
- Pulse Intravenous Cyclophosphamide Treatment for Steroid-resistant Interstitial Pneumonitis Associated with Polymyositis
- Relapsing Polychondritis Associated with Subclinical Sjogre's Syndrome and Phlegmon of the Neck
- β1-Integrin mediates cell adhesion, haptotaxis, and chemokinesis of hepatoma cells
- Unusual Accumulation of Glycogen in Liver Parenchymal Cells in a Patient with Anorexia Nervosa
- Clinical usefulness of serum HBV DNA measurement with a non radioactive chemiluminescence method
- Antibody response to inactivated hepatitis A vaccine
- Liver-Associated Natural Killer Activity in Cirrhotic Rats
- Characteristics of complete responders to interferon among patients with chronic hepatitis C with high serum levels of RNA
- Effect of acute cigarette smoking on splanchnic hemodynamics in normal volunteers
- Epidemiologic study of anti-HCV antibody reactivity with immunoblot assay
- Symposium on Clinical Aspects in Hepatitis Virus Infection, Hepatitis Virus and Extrahepatic Manifestations - Skin, Mucosa, Muscle, and Hematopoietic Organs -
- Three Cases of Renal Angiomyolipoma
- Recurrent patterns and prognosis following resection of hepatocellular carcinoma
- Treatment of Advanced Hepatocellular Carcinoma
- Diagnostic imaging of patients with focal nodular hyperplasia of the liver
- Sarcoidosis Accompanied by Pancreatic Impairment.
- Inflammatory Pseudotumor of the Liver. MR imaging Findings.:MR imaging Findings
- Fatal Acute Hepatitis B Virus Infection while Receiving Immunosuppressants after Renal Transplantation.
- Negative-strand HCV RNA Was Not Detected in Bone Marrow Cells of Patients with HCV Infection.
- Prevalence of Gastroesophageal Varices Supplied by Intrahepatic Portal Branch.
- Evaluation of Third Generation Anti-HCV Test Kit (SYNPEPTM HCV-EIA II) Using Sera of Inhabitants from HCV Hyperendemic Area.
- Two Fatal Cases of Hepatitis B Virus Carriers after Corticosteroid Therapy for Bronchial Asthma.
- Comparative Study of Magnetic Resonance Imaging, Computed Tomography and Histology in the Assessment of Liver Iron Overload.
- Mutations of Glucocorticoid Responsive Element of HBV DNA.
- A Case of Chronic Hepatitis C with Sinus Bradycardia during IFN Therapy.
- ELECTRON MICROSCOPIC OBSERVATION OF THIORIDAZINEINDUCED HEPATITIS
- ELECTRON MICROSCOPIC OBSERVATION OF THE INTRANUCLEAR GLYCOGEN OF THE LIVER IN DIABETES MELLITUS
- ELECTRON MICROSCOPIC OBSERVATION OF THE LIVER IN GILBERT'S DISEASE