Fatal Acute Hepatitis B Virus Infection while Receiving Immunosuppressants after Renal Transplantation.
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概要
- 論文の詳細を見る
A 47-year-old man with acute hepatitis B virus (HBV) infection who had been receiving immunosuppressants after renal transplantation developed progressive liver failure. During the clinical course (approximately 7 months), anti-HBc IgM antibody and HBV-DNA polymerase levels remained high, but the serum alanine aminotransferase (ALT) level was consistently less than 150 K.U. Histopathologic examination of the liver showed submassive hepatic necrosis without significant inflammation accompanied by marked fibrosis. Most hepatocytes showed strong nuclear expression of HBc antigen by immunohistochemical staining and electron microscopy revealed numerous intranuclear core-like particles. Hepatitis B virus infection in immunosuppressed individuals occasionally insidiously progresses, resulting in liver failure. The clinical course of such patients thus merits close scrutiny.(Internal Medicine 32: 547-551, 1993)
- 社団法人 日本内科学会の論文
著者
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Kumashiro Ryukichi
The Second Department Of Medicine Division Of Kidney Disease And Critical Care Medicine Kurume Unive
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Tanikawa Kyuichi
The Second Department Of Internal Medicine Kurume University School Of Medicine
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TAGUCHI Jun
the First Department of Pathology, Kurume University of Medicine
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KOGA Yuriko
the Second Department of Internal Medicine, Kurume University of Medicine
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SATA Michio
the Second Department of Internal Medicine, Kurume University of Medicine
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SAKISAKA Shotaro
the Second Department of Internal Medicine, Kurume University of Medicine
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HINO Teruko
the Second Department of Internal Medicine, Kurume University of Medicine
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KAGE Masayoshi
the First Department of Pathology, Kurume University of Medicine
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HAMADA Takaomi
the Second Department of Internal Medicine, Kurume University of Medicine
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FURUDERA Shigeki
the Second Department of Internal Medicine, Kurume University of Medicine
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TANIKAWA Kyuichi
the Second Department of Internal Medicine, Kurume University of Medicine
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KUMASHIRO Ryukichi
the Second Department of Internal Medicine, Kurume University of Medicine
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