Negative-strand HCV RNA Was Not Detected in Bone Marrow Cells of Patients with HCV Infection.
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概要
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To determine whether hepatitis C virus (HCV) replicates in bone marrow, we investigated positive-and negative-strand HCV RNA in bone marrow cells and fluids, and sera from patients with HCV infection. The study population consisted of 15 patients positive for antibodies to HCV (anti-HCV). Positive- and negative-strands HCV RNA were detected using highly strandspecific rTth reverse transcription-polymerase chain reaction (rTth RT-PCR) followed by Southern blotting analysis. Positive-strand HCV RNA was detected in 12 (80%) serum samples, in 13 (86.7%) bone marrow fluid specimens, and in 6 (40.0%) bone marrow cell samples. Negativestrand HCV RNA was detected in 9 (60.0%) serum samples, 11 (91.7%) fluid specimens, while it was not detected in bone marrow cells. The absence of negative-strand HCV RNA in bone marrow cells suggested that HCV does not replicate in these cells. Negative-strand HCV RNA detected in serum and bone marrow fluid samples may have been due to contamination with circulating HCV RNA from hepatocytes.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SUZUKI Hiroshi
The Second Department of Medicine, Kurume University School of Medicine
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NAGAO Yumiko
Department of Oral Surgery, Kurume University School of Medicine
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Ide Tatsuya
The Second Department Of Medicine Division Of Kidney Disease And Critical Care Medicine Kurume Unive
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Tanikawa Kyuichi
The Second Department Of Internal Medicine Kurume University School Of Medicine
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IDE TATSUYA
The Second Department of Medicine, Kurume University School of Medicine
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NAGAO YUMIKO
Department of Oral Surgery
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SATA Michio
the Second Department of Internal Medicine, Kurume University of Medicine
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NOGUCHI SEIJI
The Second Department of Medicine, Kurume University School of Medicine
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