The Predictive Value of p53, Ki-67 and Angiogenetic Factors in Primary Hypopharyngeal Carcinoma.
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the predictive role of the oncogene p53, the proliferating marker Ki-67, angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase (PDECGF/dThdPase) and vascular endothelial growth factor (VEGF) in primary hypopharyngeal carcinoma, we immunohistochemically studied a series of 84 primary hypopharyngeal carcinoma patients who were treated at the Department of Otolaryngology of Kurume University Hospital between 1990 and 1997. The correlation of each score according to the intensity and percentage of the labeled cells with the TNM stage, histological grade, metastasis and survival status was analyzed. The positive rate of p53 was 52.4%. The percentages of Ki-67 labeled cells in patients with or without metastasis showed a significant difference (p=0.011). VEGF also showed a significant difference between the live and death groups (p<0.05) and also among the differentiation group (p<0.05). A statistically significant correlation was also seen between the score of Ki-67 and VEGF (r=0.438, p<0.001) or the score of Ki-67 and PD-ECGF (r=0.259, p<0.001), respectively. In conclusion, the present study suggests that a correlation exists between proliferating and angiogenesis, and VEGF and Ki-67 are thus considered to be possible prognostic discriminators in hypopharyngeal carcinoma.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Mori Kazunori
Department Of Microbiology Showa University School Of Pharmacy
-
Nakashima Tadashi
Department Of Otorhinolaryngology Faculty Of Medicine Kyushu University
-
MIYAJIMA YOSHIMI
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
-
DONG PIN
Department of Otolaryngology, The Shanghai First People's Hospital
-
SAKATA KAZUNARI
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
-
CHIJIWA KEI-ICHI
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
-
DONG PIN
Department of Otolaryngology, The Shanghai First People's Hospital
関連論文
- Gene Expression Profiling Identifies a Role for CHOP During Inhibition of the Mitochondrial Respiratory Chain
- BASIC STUDY ON MEMBRANE-ACTIVE AGENTS THAT POTENTIATE ANTICANCER ANTIBIOTICS
- A recurrent case of osteosarcoma of the maxilla
- Tracheal intubation in a patient with undetectable tracheal narrowing on chest radiography
- On the Improvement of English Lesson : An Approach to English Teaching in English
- Swallowing Function in Patients who Underwent Hemiglossectomy and Reconstruction with a Pectoralis Major Myocutaneous Flap
- Ki-1 Positive B-cell Lymphoma with Bizarre Giant Cells : An Electron Microscopic Study
- Reliable, Minimally Invasive Oromandibular Reconstruction Using Metal Plate Rolled with Pectoralis Major Myocutaneous Flap
- The importance of literary texts in language teaching
- The use of chat rooms for English learning
- Vehicle Cornering Characteristics in Acceleration and Braking through Attitude Control of Front and Rear Tires
- Sertoli-stromal Cell Tumor Containing Metastatic Lung Cancer Tissue.
- Comparison of Preoperative Fine-needle Aspiration Cytology Diagnosis and Histopathological Diagnosis of Salivary Gland Tumors
- The Predictive Value of p53, Ki-67 and Angiogenetic Factors in Primary Hypopharyngeal Carcinoma.