ARTERIAL ACID MUCOPOLYSACCHARIDES FOLLOWING VITAMIN D INDUCED INJURY

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Several extensive studies have been published on the histological aspects of vascular and other injuries inducible by vitamin D intoxication. Vitamin D toxicity brings skeletal changes with increased level of blood calcium and calcification in soft tissues . On the calcification of the vascular system it was reported to be prominent in vitamin D toxicity in several animal Species. However, very little information is available about the quantitative chemical changes in various connective tissue components, especially in arteries. It might, therefore, be of impotance to evidence how the change of AMPS relate with the accompanied accumulation of mineral salts in the area of tissue calcification.Former studies in this field, however, were carried out only on the level of total AMPS or acidic polysaccharides mixture, by determining the incorporation of radio active sulfate (<SUP>35</SUP>SO<SUB>4</SUB>) administered or total hexosamine manifested in the tissue, chiefly from the histochemical standpoint.Recently Gore and Tanaka have had an improved fractionation method of AMPS, and ovserved the changes of AMPS in certain aortic injuries, with attention to the relationship between their individual fractions (HA, HMS, DS and CSap).The present paper involves a study on an aortic injury induced by hypervitaminosis D, out of the series studies mentioned above, especially concerning to the analyse of individual fraction patterns.
久留米大学医学部 The Kurume Medical Journal 編集部の論文

ARTERIAL ACID MUCOPOLYSACCHARIDES FOLLOWING VITAMIN D INDUCED INJURY

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