Comparative changes of alterial blood keton body ratio and hepatic function induced by transcatheter arterial embolization and intra-arterial injection of lipiodol-adriamycin suspension in patient with liver cancer.

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Arterial blood keton body ratio (AKBR) reflects an energy charge in the cells of the liver and is a sensitive parameter to learn functional profile of the liver. Therefore, we measured the value to estimate changing aspects of the liver function after transcatheter arterial embolization (TAE) and intra-arterial injection of lipiodol-adriamycin suspension (LA) in patients with liver cancer.<BR>Seventy-one patients were treated with the following four group modalities. 1) C-TAE group (15 patients); TAE was carried out using sliced gelfoam pieces after intra-arterial administration of mitomycin-c (Conventional TAE), 2) L-TAE group (35 patients); TAE was completed using sliced gelfoam pieces after intra-arterial injection of LA, 3) LA group (17 patients); LA was achieved via hepatic artery, and 4) control group (4 patients); Only hepatic arteriography was performed.<BR>In patients of both C-TAE and L-TAE groups AKBR decreased immediately after treatment; in a half of them the value decreased continuously for two hours and increased 24 hours later. Changes of the liver function parameter were temporary in the majority of patients treated with these modalities. However, AKBR in some patients associated with severe liver cirrhosis, jaundice or markedly extended liver carcinoma decreased below 0.3 after TAE and these patients died of hepatic insufficiency. On the other hand, AKBR did not decrease in LA group and showed an increasing tendency two hours later. Moreover, no remarkable changes in liver function was induced on LA group and LA was also safe in patients with severe liver cirrhosis, jaundice or liver carcinoma mass in a large size.
社団法人日本肝臓学会の論文

Comparative changes of alterial blood keton body ratio and hepatic function induced by transcatheter arterial embolization and intra-arterial injection of lipiodol-adriamycin suspension in patient with liver cancer.

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