:a clinicopathologic study of cholangiocarcinoma

概要

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Among 3203 autopsies in adult at Pathology Department of Kurume University Hospital during the 12 years from 1971 to 1982, cholangiocarcinoma was seen in 45 cases (1.4%). The 45 cases of cholangiocarcinoma were classified into two types, peripheral type (10 cases) and hilar type (35 cases). Age ranged from 41 to 81 years old and the average was 63.0±11.4 years old. Male to Female ratio was 28:17. Main clinical symptoms were right chest pain, abdominal pain, and general malaise in the peripheral type, and were jaundice and general malaise in the hilar type. Jaundice was seen in 94.3% of the hilar type during the course, but was 40.0% of the peripherl type. Furthermore, jaundice was not seen in the peripheral type as an initial symptoms, but it was seen 40.0% of the hilar type. Mixed macro-and micronodular cirrhosis and biliary cirrhosis associated in 4 cases, respectively. Stones of the intra-and extrahepatic bile ducts were associated in 6 cases among the 10 cases of the peripheral type, and in 7 cases among the 35 cases of the hilar type. Histologically, most of the cases were well-differentiated adenocarcinoma and were accompanied by abundant fibrous stroma. Carcinoembryonic antigen was demonstrated in all the cases by immunoperoxidase technique. Metastases were seen in 35 out of 45 cases (77.8%) and there was no difference as to frequency and ratio of metastasis between the peripheral type and hilar type.
社団法人日本肝臓学会の論文