Alterations in Human Cardiac .BETA.-Adrenoceptor Density with Aging.
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概要
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Purpose : We designed this study to investigate the mechanism of reduced cardiac β-adrenoceptor function that is associated with aging.<BR>Materials and Methods : We assessed the density and affinity of β-adrenoceptors by (-) - [<SUP>125</SUP>I] iodocyanopindolol binding in the right atrial appendages obtained from 40 patients of varying age (range : 2 to 56 years) undergoing open-heart surgery. The mean right atrial pressure and cardiothoracic ratio were measured in all of the patients.<BR>Results : There was a significant negative correlation between human right atrial β-adrenoceptor density and patient age (r = 0.575, p <0.001). Neither preoperative mean right atrial pressure nor preoperative cardiothoracic ratio was correlated with β-adrenoceptor density. The affinity of β-adrenoceptors did not correlate with patient age.<BR>Conclusions : The decrease in human cardiac β-adrenoceptor function associated with increasing age is due, in part, to the reduced cardiac β-adrenoceptor density.
- 北関東医学会の論文
著者
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Hamada Yoshiro
Second Department Of Surgery Gunma University School Of Medicine
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Tsuda Kyoichiro
Second Department Of Surgery Gunma University School Of Medicine
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Morishita Yasuo
Second Department Of Surgery
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Kasahara Koichiro
Second Department of Internal Medicine, Gunma University School of Medicine
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KASAHARA Koichiro
Second Department of Internal Medicine, Gunma University
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Anzai Tetsuo
National Shibukawa Hospital, Shibukawa, Gunma
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