肝動脈塞栓術が肝細胞癌患者のNK活性およびNK細胞表面マーカーに及ぼす影響

概要

論文の詳細を見る
The effects of the transcatheter arterial embolization (TAE) to natural killer (NK) activities and NK cell surface markers in 36 cases with hepatocellular carcinoma (HCC) were investigated. Results were summerized as follows. 1) NK activities were transiently decreased significantly after TAE, accompanied by the decrease of the number of NK surface marker positive cells. Four weeks after TAE, NK activities and the number of NK surface marker positive cells returned to previous level. 2) Effective hepatic blood flow after TAE, determined by indocyanine green clearance rate was decreased in parallel with NK activities. 3) The decrease of NK activities was not related to the extent of tumor necrosis as well as the serum cortisol levels. These results suggested that transient decrease of NK activities after TAE may reflect the hepatic ischemia and that the liver may play an important role in the regulation of NK activities and NK cells.