肝細胞癌にみられる高コレステロ-ル血症の機序について

概要

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Serum lipids and bile acid concentrations were measured in 44 patients with hepatocellular carcinoma (HCC) and 30 patients with liver cirrhosis (LC). HCC was classified into two groups according to serum total cholesterol levels. Group I was hypercholesterolemic group (>230mg/dl), and Group II, the remainder of HCC patients.<BR>Total cholesterol levels were higher in HCC than in LC. Serum squalene levels, precursor of cholesterol, were higher in Group I than in Group II and LC (Group I>Group II>LC). Serum squalene levels correlated with total cholesterol in patients with HCC (r=-0.57, p<0.05).<BR>Serum and biliary bile acid levels were similar in these three groups. Serum bile acid levels did not correlate with cholesterol levels.<BR>Serum HDL-cholesterol levels, large components of bile acid precursor, were lower in Group I than in Group II and LC (Group I<Group II<LC). And serum HDL-cholesterol levels were negatively correlated with total cholesterol levels in HCC (r=-0.52, p<0.05).<BR>These data suggested that the mechanism of hypercholesterolemia in HCC may be explained by an increased production of cholesterol and a reduced production of bile acid from cholesterol.
社団法人日本肝臓学会の論文