切除肝細胞癌DNA ploidy pattern と再発

概要

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Nuclear DNA analysis on 81 cases of hepatocellular carcinoma (HCC) were performed comparing recurrent rates, recurrent modes, and survival rates. DNA ploidy pattern was divided in diploid and aneuploid. Thirty-eight cases (46.9%) were diploid pattern and 43 were aneuploid respectively. Recurrence rate of diploid group was 60.5% and 65.1% in aneuploid group. The most frequent site of recurrence was intrahepatic in both groups. The time interval by the appearance of recurrent disease was 24.2 months in diploid group and 14.4 months in aneuploid group. In diploid group, the intrahepatic recurrence was seen with single nodule, while multiple nodule in aneuploid group. Significantly higher frequency of recurrence was found in aneuploid group. Re-resection of recurrent hepatic tumor resulted the most favorable prognosis in both groups. In the patients treated by TAE or intraarterial chemotherapy, diploid group showed better results compared with aneuploid group. Nuclear DNA analysis of HCC with recurrence promises the useful method to evaluate the biological potential of malignancy of HCC.
社団法人日本肝臓学会の論文