THE MIGRATION OF LYMPHOCYTES INTO VENOUS BLOOD IN THE POPLITEAL LYMPH NODE OF RABBITS UNDER THE CONDITION OF IMMUNIZATION

概要

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To prove the evidence of the direct transfer of lymphocytes from the lymphatic matrix into the venous blood through the vascular wall in the lymph node, a differential counting of the cell between the blood directly collected from the efferent vein and the systemic blood with a micro cannulation was carried out. The results obtained are as follows: 1) Leukocytes infiltration was found in marked degree around the venules in the lymphatic matrix and the medullary cord in the very early stage of the lymphogenous administration of antigen. 2) In the early stage, small lymphocytes were expelled from the lymphatic matrix and were increased in the lymph node vein. 3) The number of the emigrated large lymphocytes were usually in reverse proportion to that of the small lymphocytes.It is clarified that lymphocytes in lymph nodes are transfered directly into venous stream across the wall of P.C.V. under the stimulated condition.
The Keio Journal of Medicineの論文