アルコ-ル肝障害の臨床病理的考察

概要

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Thirty-four patients who drank more than 80gm daily during the periods of 10 years or above were selected in order to study clinico-patholoigcal effects of alcohol on the liver. Their diagnosis was confirmed by liver biopsy and divided histologically into group A (17 patients with liver cirrhosis or pre-cirrhosis) and group B (17 patients with non-cirrhosis). 1) Physically, the group A was predisposed to hepatomegaly, jaundice, vascular spider and ascites when compared with group B. 2) The group A showed abnormality in BSP, TTT, ZST, AL-P and transaminase more frequently than group B. GOT/GPT was apt to be over 1 in group A. 3) Study estimated a relationship between alcohol consumption and histological findings of the liver and suggested that heavy drinker who had drunk more than 200gm daily during the periods of 15 years or above tended to be included in group A. 4) Electron microscopic study demonstrated crystalloid materials (periodicity 160A) in the cytoplasmic materials as a special finding. 5) Serial liver biopsies in one case demonstrated a four years' course of the disease reaching to postnecrotic cirrhosis.
社団法人日本肝臓学会の論文