原発性肝細胞癌とα-Fetoprotein(AFP)低産生肝癌の臨床的,病理学的検討

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Clinico-pathological studies were made in relation to serum α-fetoprotein (AFP). Of the 123 cases with hepatocellular carcinoma, there were 22 cases (17.9%) with low AFP concentration below an arbitrary line set at 400ng/ml in whom little change of AFP was observed during the course of their illness. On the contrary, those with high AFP levels usually showed increased AFP concentration proportionally to growth or progression of the tumor in the majority.<BR>There was an tendency that the low AFP cases show well differentiated tumors such as grade I and II according to Edmondson-Steiner's classification. The positive rate for HBAg by radioimmunoassay were 77.3% in the low AFP cases and 46.5% in the high AFP patients, which was significantly different.<BR>Longer survival times were demonstrated in low AFP patients with or without anticancer chemotherapy.<BR>In addition, HBAg and AFP were analyzed on 14 cases of hepatocellular carcinoma accompanied by hepatic Schistosomiasis japonica. Out of the 14 cases, 5 cases (28.6%) were positive for HBAg, and 8 cases showed relatively low AFP levels (negative by agar gel diffusion method). It is not feasible to conclude that chronic hepatic Schistosomiasis is etiologically directly related to hepatocellular carcinoma and AFP levels.<BR>A localized small hepatocellular carcinoma was found in each of two autopsied cases with a high AFP level which solely was indicative of the hepatocellular carcinoma while being alive.
社団法人日本肝臓学会の論文

原発性肝細胞癌とα-Fetoprotein(AFP)低産生肝癌の臨床的,病理学的検討

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