A study of response of coagulation and fibrinolysis factors to the venous occlusion test in patients with collagen diseases-differencies between those with or without lupus anticoagulant.

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Changes in kinetics of blood coagulation and fibrinolysis factors, when assayed with endothelium by the venous occlusion (VO) test, were studied in patients with SLE and PSS, especially seeking any discrepancies between those with and without lupus anticoagulant (LA).There was no significant difference in the blood concentration of plasminogen activator inhibitor-1 (PAI-1) between patient and control groups both before and after VO test. On the other hand the tissue plasminogen activator (tPA) in patient group showed a relatively smaller increment than in control group before versus after the test, and the Factor VIII related antigen (FVIIIR: Ag) in the former group was statistically higher than in control group both before and after the test (p<0.01). The tPA in LA positive patients was remarkably lower than in LA negative SLE patients and control group both before and after the test (p<0.01), but no significant difference was found in the FVIIIR: Ag between the two subpopulations at either monitoring.These results suggest that the major causes of thrombosis frequently observed in patients with collagen diseases, especially in those with LA, could involve depressed production of tPA from the endothelium.
日本臨床免疫学会の論文