Clinical significance of measurement of serum adenosine deaminase and neopterin levels in patients with HIV infection.

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The concentrations of adenosine deaminase (ADA) and neopterin (NP), known to be released from activated lymphocytes and monocytes/macrophages, were measured in the sera of hemophiliacs with human immunodeficiency virus (HIV) infection to study whether these measurements were useful or not as early predictors for development to ARC and full blown AIDS.The mean concentration of ADA in sera of 38 hemophiliacs with anti HIV antibody (54.0±17.7IU/l) was higher as compared with that of 30 patients without the antibody (38.6±13.9IU/l) with statistical significance (p<0.01) and this tendency was observed more clearly in those with a reversed CD 4/CD 8 lymphocyte ratio (p<0.01).The concentration of NP was also significantly higher in anti HIV antibody positive group (24.9±18.3nmol/l) than that of negative one (7.9±4.2nmol/l) (p<0.01), and this tendency was more prominent in patients with CD 4/CD 8 lymphocyte ratio less than 0.2 (p<0.01).Moreover the concentrations of ADA and NP, measured serially in sera of 4 patients who developed AIDS, gradually increased in accordance with and/or ahead of the decreases in anti p24 antibody titer and CD 4/CD 8 lymphocyte ratio and reappearance of HIV, but turned ot decrease at their terminal stages.From these, it was suggested that in patients with HIV infection, serial measurement of serum ADA and NP levels, combined with check-ups on anti p24 antibody, HIV and CD4 and CD8 lymphocyte counts was clinically useful and important to predict and find their development to ARC and AIDS, and manage them in advance.
日本臨床免疫学会の論文

Clinical significance of measurement of serum adenosine deaminase and neopterin levels in patients with HIV infection.

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