DEPRESSOR MECHANISM OF SYNTHETIC ACTH (50022)
スポンサーリンク
概要
- 論文の詳細を見る
Tanaka et al. (1) have discovered the potent adrenocorticotropic activity of (Gly<SUP>1</SUP>)-ACTH (1-18)-octadecapeptide amide (50022), one of the synthetic polypeptide synthesized by Otsuka et al. (2), as well as its lypolytic and MSH activities.<BR> Since ACTH has several extra-adrenal effects such as induction of stretching and yawning syndrome (3), sexual excitement (4), inhibition of the extinction of conditioned avoidance behaviour (5-7), hypoglycemic effect (8), in addition to its lypolytic and MSH activities, extensive pharmacological studies have been carried out on 50022 (9). The only noteworthy pharmacological effect observed with 50022 was a depressor effect seen in cats and rabbits on intravenous injection.<BR> This experiment was undertaken to investigate the depressor mechanism of 50022 in experimental animals and to further compare the vascular effect of 50022 with that of vasoactive polypeptides.
- 社団法人 日本薬理学会の論文
著者
-
川上 勝
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
上田 元彦
Shionogi Research Laboratories Shionogi & Co. Ltd.
-
武田 寛
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
松田 三郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
川上 勝
Shionogi Research Laboratory, Shionogi & Co., Ltd.
-
松田 三郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
関連論文
- Synthesis and Evaluation of Novel Pyrazolo[1,5-a]pyrimidine Derivatives as Nonpeptide Angiotensin II Receptor Antagonists
- Studies on Dihydropyridines. III. : Synthesis of 4,7-Dihydrothieno[2,3,-b]-pyridines with Vasodilator and Antihypertensive Activities
- S-Alkoxycarbonylthiamineのラットにおける致死機構の解析
- O, S-Dicarbethoxythiamineの心律動におよぼす影響 : (I)実験的各種不整脈にたいする作用
- Synthesis of 2,3-Dihydro-1,4-benzodioxin Derivatives. I. : 2-Substituted-5(and 6)-sulfamoyl-2,3-dihydro-1,4-benzodioxins
- 6.O-Dimethylcarbamoyl-carbetoxythiamine(CCET)の薬理作用(ビタミンB研究委員会 : 第189回会議研究発表要旨)
- O, S-Dicarbethoxythiamineの心律動におよぼす影響 : (II)Methacholine心房細動にたいする作用
- 2.CAT類の一般薬理作用(II.薬理作用)(S-Carbalkoxythiamineにかんする小委員会報告)
- S-Carbalkoxythiamine類にかんする研究 : (IV)S-Carbalkoxythiamine類の一般薬理作用について
- Dobutamineのイヌ呼吸，血圧，および数種血液成分に対する作用
- Desoxycorticosterone(DOC)/saline高血圧ラットにおけるThiazide系薬の抗高血圧作用と循環動態に及ぼす影響
- RESISTANCE OF MECHANICAL AND ELECTRICAL RESPONSES TO HYPOGASTRIC NERVE STIMULATION TO α-BLOCKING AGENTS IN GUINEA-PIG VAS DEFERENS
- EFFECTS OF ENZYME INHIBITORS ON JUNCTION POTENTIALS IN RESPONSE TO ADRENERGIC NERVE STIMULATION
- EFFECT OF ACETYLCHOLINE ON THE ELECTRICAL ACTIVITY OF CULTURED CHICK EMBRYONIC HEART
- 新抗高血圧薬Pinacidilに関する薬理学的研究 : 3．サル摘出動脈弛緩作用と末梢性降圧機序
- 新抗高血圧薬Pinacidilに関する薬理学的研究 : 2. 降圧機序の検討
- 1. SHR, DOC/saline高血圧ラットにおける抗高血圧作用 : 新抗高血圧薬Pinacidilに関する薬理学的研究
- 高血圧自然発症ラット(SHR)におけるPindololの降圧作用に対する急性耐性について
- 高血圧自然発症ラット(SHR)の血行動態に及ぼすβ遮断薬の影響
- Cefamandoleの一般薬理作用-2-呼吸,循環系および自律神経系に対する作用 (Cefamandole)
- 心収縮力，心律動におよぼすDobutamineと数種Catecholamineの作用比較
- DEPRESSOR MECHANISM OF SYNTHETIC ACTH (50022)
- N-diethylaminoethyl-reserpine (Bietaserpine)の血圧下降作用
- PRESSOR MECHANISM OF VINCRISTINE SULFATE
- EFFECTS OF THIAMINE AND S-CARBALKOXYTHIAMINE (S-CAT) ON THE STRIATED MUSCLE II.:PHARMACOLOGICAL STUDIES ON THE TWITCH POTENTIATION OF O, S-DICARBETHOXYTHIAMINE (DCET)