RESISTANCE OF MECHANICAL AND ELECTRICAL RESPONSES TO HYPOGASTRIC NERVE STIMULATION TO α-BLOCKING AGENTS IN GUINEA-PIG VAS DEFERENS

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In spite of the availability of much evidence showing the sympathetic nature of the hypogastric nerve innervating the guinea-pig vas deferens (1-8) a persistent resistance of the contractile response to hypogastric nerve stimulation to various adrenergic α-blocking agents in vitro has still remained unexplained.<BR> Boyd et al. (9) and Ohlin and Strömband (10) observed that the contractile response to hypogastric nerve stimulation was not depressed by moderate doses of various α-blocking agents but rather potentiated owing to their anti-cholinesterase activity. Burnstock and Holman (8) have also demonstrated that the junction potentials in response to hypogastric nerve stimulation had a considerable resistance to the α-blocking agents in the guinea-pig vas deferens in vitro.<BR> The present study was, therefore, designed to reappraise the well known in vitro resistancy, of mechanical and electrical responses of guinea-pig vas deferens to hypogastric nerve stimulation to α-blocking agents, using an in vivo preparation, in which the intravenously administered drugs would reach the receptor sites through the blood stream with active pressure.
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