Halothane-induced relaxation of vascular smooth muscle: A possible contribution of increased cyclic GMP formation.
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概要
- 論文の詳細を見る
Halothane (0.75 to 2.25%) dose-dependently relaxed the vascular smooth muscle of endothelium-denuded rat aortae previously contracted with KCl, and the relaxing effect was not significantly affected by indomethacin nor dexamethasone, but partly inhibited by methylene blue. The cyclic GMP levels were increased by treatment with halothane (2.25%). It was suggested that halothane-induced relaxation of vascular smooth muscle is partly mediated by cyclic GMP formation.
- 公益社団法人 日本薬理学会の論文
著者
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Hatano Yoshio
Department Of Anaesthesiology Tenri Hospital
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Mori Kenjiro
Department Of Anesthesia Kyoto University Hospital
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Nakamura Kumi
Department Of Anesthesia Kyoto City Hospital
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Toda Hiroshi
Department Of Anesthesia Kyoto University Hospital
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Nishiwada Makoto
Department Of Anesthesiology Tenri General Hospital
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Toda Hiroshi
Department of Anesthesia, Kyoto University Hospital
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Hatano Yoshio
Department of Anesthesia, Kyoto University Hospital
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Baek Woon-Yi
Department of Anesthesia, Kyoto University Hospital
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- Halothane-induced relaxation of vascular smooth muscle: A possible contribution of increased cyclic GMP formation.