上顎洞粘膜内細菌の臨床的,細菌学的ならびに病理組織学的研究

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Attempts were made of the clinical, bacteriological and histo-pathological studies on bacteria within the maxillary sinus mucosa to clarify their etiological significance in the causes of maxillary sinusitis. Results obtained were as follows:1. Gram-negative bacilli which were predominant in the pus (Table 1) were hardly found in the mucous membrane, while cocci and diplococci were equally present both in the pus and mucous membrane (Table 2 and 4).2. In general, the bacteria were observed more in the middle or deeper layer of the mucous membrane than in the superficial layer. Few bacteria were found in the area associated with marked cellular infiltration and most of them were within phagocytes. They were numerous in the edematous areas with slight cellular infiltration and around thickened blood vessels.3. No statistically significant relationship was present between the number of the bacteria in-the mucous membrane and the duration of symptoms of the individual patients examined (Table 5).4. It was ascertained that macroscopically edematous hypertrophic membrane contained numerous bacteria and the membrane appearing almost normal was contaminated with few bacteria (Table 6).5. The number of bacteria within the mucous membrane of a sinus was in proportion to the quantity and the foul smell of the pus in the sinus, and not to the stickiness of the pus (Table 7).6. The relationship between eosinophilic infiltration in the mucous membrane and bacterial allergy was not evident as shown in Table 9.7. According to histological types of the affected mucous membrane, the bacteria were found less in the infiltrative or normal type, and more in the edematous or fibrotic type (Table 8).8. The origin of respective histological type following bacterial infection was assumed from above observations. Infiltrative type with numerous plasma cells and lymphocytes may be formed as chronic allergic productive inflammation due to bacterial allergy.
社団法人日本耳鼻咽喉科学会の論文

上顎洞粘膜内細菌の臨床的,細菌学的ならびに病理組織学的研究

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