Immunohistochemical Studies of CD 45 RO-and CD 45 RA-Positive Cells and IgG Subclass-Producing Cells in Ulcerative Colitis.

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The distribution and localization of lymphocyte subsets, CD45RO- and CD45RApositive cells, and IgG subclass-producing cells were immunohistochemically studied in the colonic mucosa of 32 patients with ulcerative colitis (UC). In UC cases lymphoid follicles were increased in the colonic mucosa and IgG subclass-producing cells, especially IgG1 positive cells were significantly increased around them as compared to controls. CD45RApositive cells were also aggregated around the lymphoid follicles, while CD45RO-positive cells were increased in the lamina propria. Double staining method revealed that most of the increased CD45RA-positive cells around the lymphoid follicles were CD3 -CD20-, while those in them were CD3-CD20+. These findings suggested that CD45RO- and CD45RApositive cells, correlating with the increase in IgG subclass-producing cells around the lymphoid follicles, may play an important role in prolonged inflammation and immunological pathogenesis of UC.
日本大腸肛門病学会の論文