大腸多発癌の臨床病理学的検討

概要

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During the ten years from January 1981 to December 1990, 47 cases with multiple primary carcinomas of the large bowel were operated on in our department. These 47 cases accounted for 5.6% of the total cases (835) with carcinoma of the large intestine.<BR>Of the 47 patients, 38 were designated as multiple synchronous colorectal cancer, while 9 cases were designated as multiple interval colorectal cancer. The incidence of cases with adenomatous polyps among the 47 cases with multiple colorectal cancer was 42.6%, which was significantly higher than 14.0% among the 749 cases with single cancer (p<0.01). The cumulative 5-year survival rate of the 47 cases with multiple primary carcinomas of the large bowel was 61.2%, which was nearly the same as 62.3% recorded for the 749 cases with single cancer. 22 (46.8%) of 47 cases with multiple colorectal cancer had a family history of cancer, while only 23.9% of the 749 cases had a family history of cancer (p<0.01). The hereditary factor seems to be related to the cause of multiple primary carcinomas of the large bowel. We recommend an examination of the entire colon preoperatively, during the operation and postoperatively as many times as possible.
日本大腸肛門病学会の論文