高カルシウム血症を合併した直腸Ra原発扁平上皮癌の1例

概要

論文の詳細を見る
We report a case of a "pure" squamous cell carcinoma arising in the middle rectum in a patient who presented with severe hypercalcemia. "Pure" squamous cell carcionma of the large bowel is a distinctly rare entity. There have been 51 documented cases reported in the English literature to date. We believe that this is first case found to be associated with severe hypercalcemia.<BR>A 44-year-old man was admitted to out hospital with a four-month history of melena. The ulcerative type of tumor was detected 10 cm above the dentateline by sigmoidoscopy, and biopsy confirmed anaplastic carcinoma. Laparotomy and low anterior resection were performed, and no distant metatases were seen at that time.<BR>Four months after operation, he complained of feverishness and palpitation. Liver metastses and elevation of 'the serum calcium level (max. 9.6 mEq/I) were detected. Only mithramycin was effective against hypercalcemia. He died of chronic DIC nine months after operation.<BR>Autopsy was performed, and histologic examination of the hepatic metastases revealed poorly differentiated squamous cell carcinoma with typical epithelial pearls and keratinzation. No mucin secretion was found. Parathyroid glands were normal, and only small bone metastasis of the sternum was seen. The surgical specimen was also examined. Tumor invasion extended beyond the bowel . wall, and metastases to the regional lymph nodes were found (Duke's stage .C).<BR>Previous reported cases are reviewed, and pathogenesis of squamous cell carcinoma of the large bowel and hypercalcemia'are discussed.

高カルシウム血症を合併した直腸Ra原発扁平上皮癌の1例

スポンサーリンク

概要

著者

関連論文

スポンサーリンク