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This experiment was carried out to see the effect of high fat diet on the induction of colon carcinoma/adenoma in rats by N-methyl-N'-nitro-N-ni trosoguani dine (MNNG). Two groups of rats fed on two different dose of fat diet, including 11 per cent and 5 per cent of fat dose were used. Comparison of the incidences of colon adenoma between the two groups revealed a significant difference. Incidence of adenoma of the colon in high fat diet group was 81.8 per cent, wheras it was 33.3 per cent in control group (p<0.05).<BR>However there was no significant difference in the incidence of colonic carcinoma between them. Two cases with carcinoma in adenoma were also detected in high fat diet group.<BR>From these results, it was concluded that the effect of high fat diet on carcinogenesis of the colon might disappear with the more effective carcinogen itself, however it would bring light on the research of malignant change from adenoma due to the evidence of higher induction of adenoma of the colon by MNNG.
日本大腸肛門病学会の論文