Changes in Pulsatile Coronary Blood Flow Induced by Coronary Vasodilators
スポンサーリンク
概要
- 論文の詳細を見る
Nine mongrel dogs were sacrificed to know hemodynamic effect of nitroglycerin, dipyridamole and theophylline ethylendiamine on coronary circulation.Coronary blood flow (CBF) was measured by electromagnetic flowmeter. Aortic and left ventricular pressure were measured at the same time. Arterial and coronary sinus oxygen tension were measured.Dipyridamole gave effect of marked and continuous increase in CBF, decrease in coronary vascular resistance (CVR) and raised coronary sinus oxygen tension.Nitroglycerin gave effect of increase in heart rate immediately after the injection, followed by decreased heart rate and decrease in TTI 3min. later.Theophylline ethylendiamine gave effect of decreased CVR and TTI immediately after the injection, however, noteworthy change could not be seen 3min. later.The types of change in coronary vascular resistance induced by coronary vasodilators were divided into 3 groups.In group A, decrease in systolic CVR without decrease in enddiastolic CVR (EDCVR) was seen. Here, decrease in TTI with increased heart rate was seen.In group B, coronary vasodilation in enddiastole without decrease in mean CVR was seen. Probably, extravascular compression played an important role here.In group C, reduction of CVR in systole and enddiastole was seen with decrease in TTI/CBF ratio and lowered aortic pressure, suggesting extravascular compression was rather indifferent.
- International Heart Journal刊行会の論文
著者
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NAKAMURA Yoshiro
Department of Chemistry, Faculty of Science, Konan University
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Nishikawa Yasuhiro
Cardiopulmonary Division Dept. Of Med. School Of Med. Keio Univ.
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Nakamura Yoshiro
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Nagoshi Hideki
Department of Cardiology The Second Tokyo National Hospital
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Sasamoto Hiroshi
Department Of Internal Medicine Keio University Hoipital
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Nishikawa Yasuhiro
Department Of Internal Medicine School Of Medicine Keio University
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Nishikawa Yasuhiro
Cardiopulmonary Division Department Of Internal Medicine School Of Medicine Keio University Tokyo
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TAKEI Fumio
Department of Medicine, School of Medicine, Keio University
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SCHÖLKENS Bernward
Department of Medicine, School of Medicine, Keio University
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Nakamura Yoshiro
Department Of Chemistry Faculty Of Science Konan University
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Sasamoto Hiroshi
Department Of Cardiology School Of Medicine Tokai University
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Nakamura Yoshiro
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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SASAMOTO Hiroshi
Department of Medicine, School of Medicine, Keio University
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SASAMOTO Hiroshi
Department of Cardiology and Cardiovascular Surgery, Tokai University Hospital
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NAKAMURA Yoshiro
Department of Medicine, School of Medicine, Keio University
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