Granulocyte Colony-Stimulating Factor-Producing Large Cell Undifferentiated Carcinoma of the Lung.
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概要
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We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.(Internal Medicine 31 : 277-280, 1992)
- 社団法人 日本内科学会の論文
著者
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Uede Toshimitsu
Department of Molecular Immunology Institute for Genetic Medicine, Hokkaido University Graduate Scho
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MORI Masaki
Department of Agricultural Chemistry, University of Tokyo
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Shijubo Noriharu
Department Of Pathology Sapporo Medical University School Of Medicine
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Matsuura Akihiro
Department Of Animal Science School Of Veterinary Medicine Kitasato University
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Inoue Yuji
Department Of Dermatology And Plastic And Reconstructive Surgery Graduate School Of Medical And Phar
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Suzuki Akira
Department Of Anesthesiology And Intensive Care Hamamatsu University School Of Medicine
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SHIJUBO Noriharu
Departments of Internal Medicine, Sapporo Medical College
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MATSUURA Akihiro
Departments of Pathology, Sapporo Medical College
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HIRASAWA Michio
Departments of Internal Medicine, Sapporo Medical College
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IGARASHI Tomofumi
Departments of Internal Medicine, Sapporo Medical College
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