Correlation of Nonspecific Bronchial Responsiveness to Baseline Pulmonary Function in Patients with Asthma and Sinobronchial Syndrome.

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To examine the relationship of nonspecific bronchial responsiveness to baseline pulmonary function, and to compare the reactivity in asthma and sinobronchitis, we measured the provocative concentration of methacholine, causing a 20% fall in forced expiratory volume in one second (PC20-FEV1) in 82 asthmatic patients, 54 patients with sinobronchial syndrome and 57 normal subjects. Log PC20-FEV1 was directly correlated to baseline pulmonary function. The strongest correlation was seen between log PC20-FEV1 and baseline FEV1 as a %of the predicted FEV1 (%FEV1), both in asthma (log PC20-FEV1 = 0.020x %FEV1 - 1.988, r = 0.54, p< 0.01) and in sinobronchial syndrome (log PC20-FEV1 = 0.025 x %FEV1 - 1.233, r = 0.64, p< 0.01). From the regression equations, the mean value of PC20-FEV1 at 100% FEV1 was calculated as 1.02 and 18.5 mg/ml in asthmatic and sinobronchitic patients, respectively, and the value was 35.5 mg/ml in normal subjects. The PC20-FEV1 to %FEV1 relationship may be helpful to assess individually measured PC20-FEV1 values in patients with airway obstruction.(Internal Medicine 32: 1-5, 1993)
社団法人　日本内科学会の論文