Involvement of Thromboxane A_2 and Sulfidopeptide Leukotrienes in Cough Reflex in Response to Inhaled Capsaicin in Asthmatic Patients

概要

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Lipid mediators such as thromboxane A_2 (TxA_2) and sulfidopeptide leukotrienes (s-LTs) are released by chronic airway inflammation characteristic of bronchial asthma. Our working hypothesis for the present study was that TxA_2 and s-LTs modify and augment the airway cough sensitivity in asthma. The effects of a TxA_2 antagonist, AA-2414 (80mg/day for 7days), a thromboxane synthesis inhibitor, OKY-046 (400mg/day for 7days), and a s-LT antagonist, ONO-1078 (450mg/day for 7days), on cough response to inhaled capsaicin were examined in fifteen patients with stable asthma. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough sensitivity. The cough thresholds with AA-2414 treatment (37.6 (GSEM 1.23)μM), OKY-046 (41.2(GSEM 1.22)μM) and ONO-1078 (31.2(GSEM 1.22)μM) were significantly greater than the value with placebo (20.6(GSEM, 1.24)μM). These results support our hypothesis that TxA_2 and s-LTs released by chronic airway inflammation may be modulators augmenting airway cough sensitivity.
日本呼吸器内視鏡学会の論文
1998-01-25