Effect of Repeated Exposure to Cigarette Smoke on Airway Responsiveness in Guinea Pigs

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We examined the influence of repeated exposure to cigarette smoke on airway responsiveness to inhaled histamine in guinea pigs. Animals were divided into three groups : a group exposed to 1 cigarette per day for 2 weeks, a group exposed to 20 cigarettes per day for 2 weeks and a control group which was not exposed to cigarette smoke. Increased airway reactivity was seen in both low and high level of smoke exposure groups compared to the control group 24 hr after the last smoke exposure. Then, we investigated whether the increased airway reactivity caused by repeated exposure to cigarette smoke could increase more immediately after cigarette smoke or not. Although bronchial reactivity after acute cigarette smoke in the group exposed repeatedly to cigarette smoke was significantly greater than that in the control group, the degree of bronchoconstriction immediately after smoking in the former group was smaller than in the latter group. We concluded that repeated exposure to cigarette smoke increased nonspecific airway reactivity but decreased the degree of bronchoconstriction related to smoking. These findings suggest that smoking may be an important factor contributing to the development of chronic airway obstruction by enhancing bronchial reactivity in smokers.
日本呼吸器内視鏡学会の論文
1995-05-25