Remarkable Increase in CD26-Positive T Cells in Patients with Human T Lymphotropic Virus Type I (HTLV-I) Associated Myelopathy.
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概要
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We used two-color flow cytometric analysis to investigate CD26+ (Ta1+) cells in peripheral blood T lymphocytes from patients with human T-lymphotropic virus type-I (HTLV-I) - associated myelopathy (HAM). The percentage of CD26+ cells among CD3+ cells was markedly increased in patients with HAM, compared with anti-HTLV-I seropositive carriers (p<0.001) and seronegative controls (p<0.01). Within the subpopulation of T cells, a significantly high percentage of CD26+ cells was detected in both CD4+ and CD8+ cell populations. Furthermore, analysis of HLA-DR+T cells revealed similar results. In contrast CD4+CD45RA+ cells were significantly decreased in comparison with controls. These results suggest that immunologically activated or memory T cells found in peripheral blood may be etiologically relevant to HAM.(Internal Medicine 31 : 1081-1083, 1992)
- 社団法人 日本内科学会の論文
著者
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Nakamura Tatsufumi
The First Department Of Internal Medicine Nagasaki University
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EGUCHI Katsumi
The First Department of Internal Medicine, Nagasaki University School of Medicine
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Eguchi Katsumi
The First Department Of Internal Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Nagataki Shigenobu
The First Department Of Internal Medicine Nagasaki University School Of Medicine
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UEKI Yukitaka
the First Department of Internal Medicine, Nagasaki University School of Medicine
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KINOSHITA Ikuo
the First Department of Internal Medicine, Nagasaki University School of Medicine
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SHIBAYAMA Kohji
The First Department of Internal Medicine, Nagasaki University School of Medicine
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TSUJIHATA Mitsuhiro
the School of Allied Medical Sciences, Nagasaki University
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NAKAO Hideto
the First Department of Internal Medicine, Nagasaki University School of Medicine
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