Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Thyroid Disease in Japan
スポンサーリンク
概要
- 論文の詳細を見る
Type 1 diabetes mellitus is known to be a heterogenous disease which is frequently complicated with other autoimmune thyroid diseases (AITD). The present study was designed to investigate the clinical characteristics and HLA antigens in Japanese Type 1 diabetic patients with AITD. Subjects were 25 Type 1 diabetic patients with AITD (13 Graves disease and 12 Hashimotos thyroiditis) and 32 Type 1 diabetic patients without AITD. Compared with Type 1 diabetic patients without AITD, age at onset of diabetes was later and positive ICA persisted much longer in the diabetic patients with AITD. Compared with normal controls, DR9 was increased in the patients with AITD, while DR4 was increased in those without AITD. Type 1 diabetic patients with AITD were characterized by the late onset of diabetes, persistent ICA and increased association with DR9. These results suggest that immunological and genetic heterogeneity may exist within Japanese Type 1 diabetic patients.(Internal Medicine 31 : 1076-1080, 1992)
著者
-
Nagataki Shigenobu
The First Department Of Internal Medicine Nagasaki University School Of Medicine
-
KAWASAKI Eiji
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
TAKINO Hirofumi
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
CHIKUBA Nobuhiro
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
AKAZAWA Shoichi
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
YAMAGUCHI Yoshihiko
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
TAKAO Yukio
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
MAEDA Yasuo
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
OKUNO Shinichiro
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
YAMAMOTO Hidefumi
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
YOKOTA Atsushi
the First Department of Internal Medicine, Nagasaki University School of Medicine
-
YOSHIMOTO Masaaki
the Department of Pediatrics, Nagasaki University School of Medicine
関連論文
- Increased Production of Inflammatory Cytokines in Cultured CD4^+ Cells from Patients with HTLV-I-Associated Myelopathy
- Spontaneous Proliferation of and Cytokine Production by T Cells Adherent to Human Endothelial Cells in Patients with Human T-Lymphotropic Virus Type I-Associated Myelopathy
- Pentoxifylline Treatment in HTL-I-Associated Myelopathy
- Preoperative Treatment of Growth Hormone-Produsing Pituitary Adenoma with Continuous Subcutaneous Infusion of Octreotide
- Autoantibodies and Immunoglobulins in Atomic Bomb Survivors with Human T-Lymphotropic Virus Type I
- Improvement of Hypothyroidism after Glucocorticoid Replacement in Isolated Adrenocorticotropin Deficiency
- Comparative Study of C-Reactive Protein in Chronic Hepatitis B and Chronic Hepatitis C
- Signal Transduction of Granulocyte Macrophage-Colony Stimulating Factor in a Human Endothelium-Derived Cell Line
- A Case of Adrenal Insufficiency Due to Acquired Hypothalamic CRH Deficiency
- Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Thyroid Disease in Japan
- Locked-in Syndrome and Abnormal Orientation of the Right Vertebral Artery in a Young Man.
- Acute Adrenal Insufficiency Due to Symptomatic Rathke's Cleft Cyst.
- Remarkable Increase in CD26-Positive T Cells in Patients with Human T Lymphotropic Virus Type I (HTLV-I) Associated Myelopathy.