中枢作用,ことに行動観察について (新向精神薬,Oxazolazepamの薬理学的研究-1,2-)

概要

論文の詳細を見る
Oxazolazepam showed marked taming effects in mice, hamsters, rats and monkeys. These effects were comparable to those of chlordiazepoxide. Oxazolazepam was somewhat more potent against convulsions induced by megimide and pentetrazol and convulsion of E<SUB>1</SUB>-strain mouse but was less potent against convulsions induced by strychnine and electro shock than chlordiazepoxide. On the decrease of spontaneous locomotor activity, muscular relaxation, ataxia and loss of righting reflex in mice and tolerance of taming effects in hamsters, oxazolazepam was definitely less effective than chlordiazepoxide. On the conditioned avoidance response in rats, emesis produced by apomorphine in dogs and tremorine induced symptoms in mice, oxazolazepam was not significantly inhibitory.
社団法人日本薬理学会の論文