牛胎児甲状腺の組織学的所見

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Thyroids of 26 bovine fetuses, 10.0 to 64.5 cm in crown-rump length, were histologically examined. The number, body length, and estimated age of the fetuses are shown in table 1. The glands were fixed in Zenker-formol and embedded in paraffin. Paraffin sections were stained with hematoxylin-eosin and by Massons trichrome method, Mallory-azan method, PAS technique, and LILLIEs silver impregnation.In a 10-cm fetus, the thyroid consisted of undifferentiated epithelial cells arranged in very irregular cords. In a few of these cells, the cytoplasm contained colloid droplets, which were also seen in intercellular spaces. No follicles were present, In 12.5-and 13.2-cm fetuses, a few very young follicles with a colloid mass in the lumen were developed in the cords and spherical groups of cells, most of which were loaded with colloid droplets located in juxtanuclear portion or far from the nucleus, or polarized toward the capillary surface. From the stage of 16.3cm onwards, the whole thyroid consisted generally of follicles of widely varying size which grew progressively together with an increase in amount of colloid stored in them which stained mostly blue or occasionally yellow or red by the azan method, except the peripheral portions of the gland which presented indifferent patterns showing irregular cell masses and very young follicles.Argyrophilic granules demonstrated by LILLIEs silver impregnation appeared in fetuses 16.5cm in body length and older, first in cells of small follicles and then in these of medium-sized follicles and of interfollicular undifferentiated epithelial masses. Follicles were formed first in irreguar cell cords and, thereafter, separated by encircling of argyrophilic fibers, growing by mitotic proliferation of cells, together with their fellows developing from interfollicular undifferentiated epithelial cells.Most cells of the developing follicles contained PAS-positive, occasionally argyrophilic, granules in the apical portion of the cytoplasm being ready to cast them off into the lumen. With the advance of fetal age, colloid substances became to be seen frequently in the interstitial tissues in variable amount. They may be extravasations pushed out of ruptured follicles or passing through degenerating colloid cells in the follicular epithelium from the lumen.
社団法人日本畜産学会の論文

牛胎児甲状腺の組織学的所見

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