胎生期マウス上垂体前葉の組織・細胞学的発達

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The purpose of this study is to investigate the morphological development and the cytological differentation of the embryonic hypophysis of the mouse, using the glands of mice ranging from 12-day-old embryos to 19-day-old embryos, together with infants at birth. At the 12-day stage, the hypophyseal sac lies in the mesenchymal tissue between the diencephalon and the pontine flexure of the hind brain, pressed from the front to the back, extending laterally, attaching to the oral roof by the slightly constricted neck at its base. At the 13-day stage, thickening of the anterior wall and the lower posterior wall of the sac is noted to develop into the pars distalis. A pair of bud-like lateral lobes are found near the origin of the hypophyseal stalk. At the 14-day stage, the connective tissue fossa invades between the pars distalis and the forward-developing pars tuberalis which formerly was named the lateral lobes. Conspicuous infiltration of the connective tissue elements accompanying blood vessels into the pars distalis from the fossa is noted at the 15- and 16-day stages. At the 17-day stage, the pars tuberalis attaches to the floor of the diencephalon, extending a pair of aterior horns toward the optic chiasm and a pair of posterior horns backward to the neck of the neural lobe. At first, since the hypophysis is flattened from the front to the back, the presence of the neural lobe makes a deep depression on the dorsal surface of the hypophyseal sac. In later period, due to flattening of the hypophysis from the top to the bottom, the depression on which the neural lobe is placed becomes not so clear. Just prior to birth, the hypophysis is greatly flattened from the top to the bottom, and only the posterior part of the pars distalis is slightly thick. The fossa between the pars distalis and the pars tuberalis becomes indistinct. Differentiation of cell types of the fetal hypophysis of the mouse is made with great difficulty. The acidophil cells are rarely recognized at birth by Mallory azan technique only. The basophil cells are differentiated in a greatly small amount from the 14-day stage after application of PAS technique. PAS positive granules are so minute that they are revealed under high magnification. The PAS positive granules are stained red-purple by Wilson-Ezrin technique ('54). The basophil cells containing the granules are found in the lower peripheral and in the central region in the pars distalis, and seem to be in close contact with the reticular tissue. Here described PAS positive basophil granules are indigested by salivary immersion. Saliva-digestible glycogen granules are highly abundant in the fetal hypophysis. Glycogen appears from the 13-day stage onward and disappears at birth. The glycogen-rich feature is a characteristic of the fetal hypophysis of the mouse.
大阪府立大学の論文
1958-02-15

胎生期マウス上垂体前葉の組織・細胞学的発達

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