Autologous Cytokine-Induced Killer Cells in the Treatment of Multiple Myeloma Concomitant with Lung Cancer and Paraneoplastic Dermatoses
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概要
- 論文の詳細を見る
Cytokine-induced killer (CIK) cells have been shown to be effective in the treatment of advanced cancer and minimal residual diseases. We report a multiple myeloma (MM) patient with concomitant lung cancer and paraneoplastic dermatoses, who received cellular immunotherapy with CIK cells which were derived from peripheral blood mononuclear cells (PBMCs) after being primed with anti-cluster of differentiation 3 (CD3) monoclonal antibody, interleukin-2 (IL-2), interferon-γ (IFN-γ) and IL-1. After treatment MM and lung cancer remained stable and no progression or recurrence was observed. Paraneoplastic dermatoses were obviously improved after treatment, which was first reported. No evident side effects were observed. These findings suggested that cellular immunotherapy with CIK cells was safe and effective in this patient with MM and lung cancer, and it might be a potent therapeutic option for paraneoplastic dermatoses.
- 社団法人 日本内科学会の論文
著者
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WANG Yao
Department of Cosmetic Applications & Management, Cardinal Tien College of Healthcare & Management
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Yang Bo
Department Of Cardiology Key Laboratory Of Cardiovascular Remodeling And Function Research Chinese M
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Lin Jie
Department Of Cardiology Kanazawa Medical University
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Han Weidong
Department Of Molecular Biology Institute Of Basic Medicine Chinese People's Liberation Army Ge
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Yang Bo
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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Zhu Hongli
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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Lu Xuechun
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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Dai Hanren
Department of Molecular Biology, Institute of Basic Medicine, Chinese People's Liberation Army General Hospital
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Dai Hanren
Department of Molecular Biology, Institute of Basic Medicine, Chinese People's Liberation Army General Hospital
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Lu Xuechun
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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Wang Yao
Department of Molecular Biology, Institute of Basic Medicine, Chinese People's Liberation Army General Hospital
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Lin Jie
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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Zhu Hongli
Department of Geriatric Hematology, Chinese People's Liberation Army General Hospital
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