Induction of Differentiation in K562 Cell Line by Nicotinic Acid-Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Nicotinic acid and nicotinamide belong to the water-soluble vitamins, and they have many physiological and pharmacological functions in various organisms. In this study, we investigated the differentiation-inducing ability of nicotinic acid-related compounds in chronic myelogenous leukemia K562 cell line. Proliferation of K562 leukemia cells was inhibited by several nicotinic acid-related compounds. Hemoglobin content was increased by nicotinic acid and by isonicotinic acid. Isonicotinic acid increased γ-globin mRNA expression as much as sodium butyrate did. The nuclei of nicotinic acid and of isonicotinic acid-treated cells decreased in size and the chromatin became more condensed. It was verified that nicotinic acid and isonicotinic acid induced erythroid differentiation in K562 cells. Expression of glycophorin A was increased by sodium butyrate. In contrast, it was decreased by nicotinic acid and by isonicotinic acid, suggesting that these compounds differentiate K562 to erythrocytes through different pathways than sodium butyrate does. Our data perhaps provide useful information as to the mechanisms of cell differentiation.
- 社団法人 日本農芸化学会の論文
著者
-
Okumura Katsuzumi
三重大学 生物資源学研究科分子細胞生物学教育研究分野
-
Okumura Katsuzumi
Laboratory Of Biological Chemistry Faculty Of Bioresources Mie University
-
Ida Chieri
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
-
Ogata Shin
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
-
TAGUCHI Hiroshi
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
-
Okumura K
順天堂大学 アトピー疾患研究センター
-
Okuma Keiko
Department Of Dermatology Juntendo University School Of Medicine
関連論文
- TWEAK inhibits TGF-β-induced contraction of normal and keloid fibroblast-embedded collagen gel
- 1-II-9 ニコチン酸関連化合物によるヒト白血病細胞K562の分化誘導における作用機構の検討(一般研究発表,日本ビタミン学会第61回大会研究発表要旨)
- 1-II-10 ニコチンアミドによるアポトーシスにおける形態変化抑制機構の解析(一般研究発表,日本ビタミン学会第61回大会研究発表要旨)
- 1-II-5 ニコチン酸関連化合物によるヒト慢性骨髄性白血病細胞K562の分化誘導効果について(一般研究発表,新世紀ビタミン学の展望と先進的展開を目指して,日本ビタミン学会第60回大会発表要旨)
- 1-II-4 ニコチンアミド処理によりヒト白血病細胞HL-60において発現が変動する遺伝子の解析(一般研究発表,新世紀ビタミン学の展望と先進的展開を目指して,日本ビタミン学会第60回大会発表要旨)
- NADワールドの新展開:最新のトピックスと展望
- Changes in the Gene Expression of C-myc and CD38 in HL-60 Cells during Differentiation Induced by Nicotinic Acid-Related Compounds
- 2-II-36 細胞死誘導時ニコチンアミド類による形態変化抑制効果に対する作用機構の解析(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
- 2-II-35 ヒト白血病細胞HL-60の分化誘導過程における細胞内NADH量の解析(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
- 2-II-34 白血病の分化誘導治療におけるニコチン酸関連化合物による併用効果の検討(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
- 2-II-17 ヒト白血病細胞HL-60の細胞死においてニコチンアミドが制御するイベント(一般研究発表,日本ビタミン学会 第58回大会研究発表要旨)
- 2-II-16 ヒト白血病細胞HL-60の顆粒球様細胞への分化誘導後に起こる細胞死の解析(一般研究発表,日本ビタミン学会 第58回大会研究発表要旨)
- 2-II-15 ヒト白血病細胞HL-60の分化誘導における遺伝子発現制御へのニコチンアミドの関与(GGA)によるmicroRNAの発現調節(一般研究発表,日本ビタミン学会 第58回大会研究発表要旨)
- Topics:複製フォーク進行制御のダイナミクス (細胞核の世界--ダイナミクスから病態まで) -- (細胞周期と細胞分裂のダイナミクス)
- 2-B-23 ニンニクの加工処理がその機能性に及ぼす影響(第57回大会一般研究発表)(第57回大会研究発表要旨)
- 2-B-11 ニコチンアミドによるヒト白血病細胞HL-60の分化誘導過程におけるミトコンドリアの関与(第57回大会一般研究発表)(第57回大会研究発表要旨)
- 2-B-10 ヒト白血病細胞HL-60の細胞死誘導過程においてニコチンアミドによる形態変化抑制効果の作用機構(第57回大会一般研究発表)(第57回大会研究発表要旨)
- 核内クロマチン構造と複製・転写のダイナミクス
- Detection of DNA Damages Induced by Five Model Chemicals in Goldfish Carassius auratus Cells Using Comet Assay
- Expression of CD38 in Human Promyelocytic Leukemia HL-60 Cell Line during Differentiation by Niacin-related Compounds(Biochemistry & Molecular Biology)
- Induction of Differentiation in Human Promyelocytic Leukemia HL-60 Cell Line by Niacin-related Compounds(Biochemistry & Molecular Biology)
- Replication Timing Properties within the Mouse Distal Chromosome 7 Imprinting Cluster(Biochemistry & Molecular Biology)
- Radical Scavenging Activities of Niacin-Related Compounds(Biochemistry & Molecular Biology)
- Apoptosis induced by Picolinic Acid-related Compounds in HL-60 Cells(Biochemistry & Molecular Biology)
- Preparation of Extended Metaphase Chromosomes from Human Cultured Cells Using a Topoisomerase II Inhibitor, ICRF-193
- Visualization of Biallelic Expression of the Imprinted SNRPN Gene Induced by Inhibitors of DNA Methylation and Histone Deacetylation
- DNA Fluorescence in situ Hybridization in Paramecium: Telomere Localization in Macronucleus : Developmental Biology
- Non-Denaturing Fluorescence in Situ Hybridization to Find Replication Origins in a Specific Genome Region on the DNA Fiber
- Roles of PU.1 in monocyte- and mast cell-specific gene regulation : PU.1 transactivates CIITA pIV in cooperation with IFN-γ
- Enzyme-Linked Immunosorbent Assays with High Sensitivity for Antigen-Specific and Total Murine IgE : A Useful Tool for the Study of Allergies in Mouse Models
- Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1
- Acne conglobata successfully treated by fractional laser after CO_2 laser abrasion of cysts combined with topical tretinoin
- IP-11 Human β-defensins and cathelicidin LL-37 on IL-31 production in human mast cells
- IP-9 Functional analysis of FCER1A-18483A>C polymorphism
- IP-7 Localization of NAD (P) H oxidase activity in allergenic pollen grains
- Benign symmetrical lipomatosis associated with alcoholism
- Protease Activity of Allergenic Pollen of Cedar, Cypress, Juniper, Birch and Ragweed
- Human umbilical cord epithelial cells express Notch1 : Implications for its epidermal-like differentiation
- Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-κB pathway and interferon-γ/dexamethasone
- Combination antibody-based cancer immunotherapy
- TGF-β type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody
- Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells
- Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli
- Inhibitory Effect of Polyphenol-Enriched Apple Extracts on Mast Cell Degranulation in Vitro Targeting the Binding between IgE and FcεRI
- GATA-1 is required for expression of FcεRI on mast cells : analysis of mast cells derived from GATA-1 knockdown mouse bone marrow
- Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-β
- Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation
- 哺乳類細胞における核内ゲノムダイナミクスの可視化技術とその応用展開を目指して
- Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes
- Apoptosis Induced by Nicotinamide-related Compounds and Quinolinic Acid in HL-60 Cells
- End Product Inhibition of the Activity of Nicotinamide Phosphoribosyltransferase from Various Tissues of Rats by NAD(Biological Chemistry)
- Findings of Nicotinamide-binding Protein in Various Mammalian Tissues and General Properties of the Protein in Hog Liver
- Effect of Cinchomeronic Acid and Related Compounds on the Growth of Radish Seedlings
- Investigation of a Scale and Slime Sensor System Constructed with Piezoelectric Quartz Crystals(Analytical Chemistry)
- Biosynthesis and Metabolism of Trigonelline in Lemna paucicostata 151(Biological Chemistry)
- Biosynthesis and Metabolism of NAD in Lemna paucicostata 151(Biological Chemistry)
- Apoptosis Induced by Niacin-related Compounds in HL-60 Cells
- The effect of antibacterial peptide human β-defensin-2 on interleukin-18 secretion by keratinocytes
- Induction of Differentiation in K562 Cell Line by Nicotinic Acid-Related Compounds
- Apoptosis Induced by the Flavonoid from Lemon Fruit (Citrus limon BURM. f.) and Its Metabolites in HL-60 Cells
- Combined Action of Purothionin and Thioredoxin on the Refolding of Recombinant Pro-urokinase(Biological Chemistry)
- Enhanced Stability of Protein Foam Due to Disulfide Bond Formation Just after Foaming(Food & Nutrition)
- Thioredoxin-catalyzed Refolding of Recombinant Protein: Refolding of Human Pro-urokinase(Biological Chemistry)
- Mapping of Human DNA-binding Nuclear Protein (NP220) to Chromosome Band 2p13.1-p13.2 and Its Relation to Matrin 3
- Induction of Differentiation in K562 Cell Line by Nicotinic Acid-Related Compounds
- Changes in the Gene Expression of C-myc and CD38 in HL-60 Cells during Differentiation Induced by Nicotinic Acid-Related Compounds
- Regulation of transcription and chromatin by methyl-CpG binding protein MBD1
- Non-Denaturing Fluorescence in Situ Hybridization to Find Replication Origins in a Specific Genome Region on the DNA Fiber
- Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells
- Finding of UDP-Glucose : Nicotinic Acid-N-glucosyltransferase Activity in Cultured Tobacco Cells and Its Properties
- Identification of N-(beta-D-Glucopyranosyl)nicotinic Acid as a Major Metabolite from Niacin in Cultured Tobacco Cells
- B-Transferase with a Pro234Ser Substitution Acquires AB-Transferase Activity
- TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis
- A Simple and Rapid Method for the Detection of Poly (ADP-ribose) by Flow Cytometry
- Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes
- Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-κB activation
- Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocytes
- A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases
- The Effects of Niacin on DNA Repair after N-Methyl-N'-nitro-N-nitrosoguanidine Treatment in Normal Human Lymphocytes
- Granulocyte and monocyte adsorption apheresis for generalized pustular psoriasis