Induction of Differentiation in K562 Cell Line by Nicotinic Acid-Related Compounds

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概要

• 論文の詳細を見る

• Nicotinic acid and nicotinamide belong to the water-soluble vitamins, and they have many physiological and pharmacological functions in various organisms. In this study, we investigated the differentiation-inducing ability of nicotinic acid-related compounds in chronic myelogenous leukemia K562 cell line. Proliferation of K562 leukemia cells was inhibited by several nicotinic acid-related compounds. Hemoglobin content was increased by nicotinic acid and by isonicotinic acid. Isonicotinic acid increased γ-globin mRNA expression as much as sodium butyrate did. The nuclei of nicotinic acid and of isonicotinic acid-treated cells decreased in size and the chromatin became more condensed. It was verified that nicotinic acid and isonicotinic acid induced erythroid differentiation in K562 cells. Expression of glycophorin A was increased by sodium butyrate. In contrast, it was decreased by nicotinic acid and by isonicotinic acid, suggesting that these compounds differentiate K562 to erythrocytes through different pathways than sodium butyrate does. Our data perhaps provide useful information as to the mechanisms of cell differentiation.

• 社団法人 日本農芸化学会の論文

著者

• Okumura Katsuzumi

  三重大学 生物資源学研究科分子細胞生物学教育研究分野

• Okumura Katsuzumi

  Laboratory Of Biological Chemistry Faculty Of Bioresources Mie University

• Ida Chieri

  Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University

• Ogata Shin

  Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University

• TAGUCHI Hiroshi

  Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University

• Okumura K

  順天堂大学 アトピー疾患研究センター

• Okuma Keiko

  Department Of Dermatology Juntendo University School Of Medicine

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