Changes in the Gene Expression of C-myc and CD38 in HL-60 Cells during Differentiation Induced by Nicotinic Acid-Related Compounds
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概要
- 論文の詳細を見る
Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation.
- 社団法人 日本農芸化学会の論文
著者
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奥村 克純
三重大院・生資・分子細胞生物学
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Okumura Katsuzumi
三重大学 生物資源学研究科分子細胞生物学教育研究分野
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Okumura Katsuzumi
Laboratory Of Biological Chemistry Faculty Of Bioresources Mie University
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Ida Chieri
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
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Ogata Shin
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
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TAGUCHI Hiroshi
Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University
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緒方 進
三重大院・生資・分子細胞生物学
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Okumura K
順天堂大学 アトピー疾患研究センター
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Okuma Keiko
Department Of Dermatology Juntendo University School Of Medicine
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