Synthesis of D- and L-Selenomethionine Double-Labeled with Deuterium and Selenium-82
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概要
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The synthesis of D- and L-selenomethionine labeled with 82Se and three deuteriums at Se-methyl group (D- and L-[2H3, 82Se]selenomethionine) was described. D- And L-[2H3, 82Se]selenomethionine were prepared by condensation of (R)- and (S)-2-amino-4-bromobutylic acid with lithium [2H3, 82Se]methaneselenolate, which was prepared from metal 82Se and [2H3]methyl iodide. The optical purities of D- and L-[2H3, 82Se]selenomethionine were determined by HPLC with a chiral stationary phase column and were found more than 99% ee. The chemical ionization mass spectra showed that the molecular related ion for N-isobutyloxycarbonyl ethyl ester derivatives of [2H3, 82Se]selenomethionine did not overlap with the m/z values known from that of non-labeled selenomethionine.
- 社団法人 日本薬学会の論文
著者
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長谷川 浩
金沢大学理工研究域物質化学系
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Shinohara Atsuko
Juntendo Univ. School Of Medicine
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HASEGAWA Hiroshi
School of Environmental Science, University of Shiga Prefecture
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Chiba Momoko
Juntendo Univ. School Of Medicine
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Matsukawa Takehisa
Juntendo University School of Medicine
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Shinohara Yoshihiko
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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Kobayashi Jun
Juntendo University School of Medicine
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Ichida Kimiyoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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Yokoyama Kazuhito
Juntendo University School of Medicine
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Shinohara Yoshihiko
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hasegawa Hiroshi
School Of Environmental Science The University Of Shiga Prefecture
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Shinohara Atsuko
Juntendo University School of Medicine
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Chiba Momoko
Juntendo University School of Medicine
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