ヒラメ白血球包囲化反応における顆粒球およびケモカインの活性
スポンサーリンク
概要
- 論文の詳細を見る
The role of leukocytes from the kidney of Japanese flounder Paralichthys olivaceus in the encapsulation response was investigated using an in vitro model. The aggregation response of leukocytes to the target fish pathogen Ichthyophonus hoferi was observed over 12 h. The cellular aggregates mainly comprised granulocytes, which were characterized by intracellular peroxidase expression. Moreover, studies of isolated granulocytes demonstrated their adhesion to I. hoferi and formation of an initial layer in the encapsulation response. We observed that mRNA expression levels of three CC-chemokines (CCL3, CCL4 and CC-CLM) and one CXC-chemokine (IL-8) increased during the encapsulation process. Among these chemokines, CC-CLM and IL-8 were actively produced by granulocytes upon stimulation by I. hoferi. Flounder granulocytes therefore appeared to play an important role in the process by releasing specific chemokines upon pathogen recognition, thereby inducing subsequent cellular recruitment leading to encapsulation.
著者
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HATAI Kishio
Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
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Wada Shinpei
Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
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Kurata Osamu
Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
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倉田 修
Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
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藤原 篤志
National Research Institute of Aquaculture, Fisheries Research Agency
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KITANCHAROEN Nilubol
Department of Fisheries, Faculty of Agriculture, Khon Kaen University
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藤原 篤志
National Research Institute Of Aquaculture Fisheries Research Agency
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Hatai Kishio
Laboratory Of Fish Diseases Nippon Veterinary And Life Science University
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Fujiwara Atushi
National Research Institute Of Aquaculture Fisheries Research Agency
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Fujiwara Atushi
National Research Institute Of Aquaculture
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Nakayasu Chihaya
National Research Institute of Aquaculture, Fisheries Research Agency
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Nakayasu Chihaya
National Research Institute Of Aquaculture Fisheries Research Agency
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Kitancharoen Nilubol
Department Of Fisheries Faculty Of Agriculture Khon Kaen University
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Kurata Osamu
Laboratory Of Fish Diseases School Of Veterinary Medicine Faculty Of Veterinary Science Nippon Veter
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Wada Shinpei
Laboratory Of Fish Diseases School Of Veterinary Medicine Faculty Of Veterinary Science Nippon Veter
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