CT画像における大腸癌検出のための特異的腹腔内脂肪蓄積の特徴量評価

概要

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In our previous study, fat tissues on abdominal CT tended to be concentrated around colon cancer sites, and the intra-abdominal fat area in patients with colon cancer presented a small secondary peak in the pelvis, which we called the sub-peak. We assessed the amount of the sub-peak to develop a novel method for early detection of colon cancer. The profile of intra-abdominal fat data was determined first by segmentation of fat components in CT images, and was approximated by removing the sub-peak part manually by use of six-degree polynominal approximation. The sub-peak value was obtained by subtracting the approximate data from the original data. The amount of the sub-peak was quantified by the sub-peak ratio which is defined by the ratio of the maximum value to the sub-peak value in the profile of intra-abdominal fat data. The subjects consisted of patients with rectal cancer (60 cases) , sigmoid colon cancer (72 cases) , and non-tumors in the pelvic cavity (59 cases) . Our result indicated that the accuracy in detecting colon cancer was 76.1% when the sub-peak ratio was equal to or greater than 10%. This amount of the sub-peak ratio may be useful in the development of a computer-aided diagnosis (CAD) scheme for early detection of colon cancer.