Methazolamide Calcium Phosphate Nanoparticles in an Ocular Delivery System
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概要
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A new system for the local delivery of methazolamide to the eye has been developed based on calcium phosphate (CaP) nanoparticles. The methazolamide loaded CaP nanoparticles were prepared through the formation of an inorganic core of CaP and further adsorption of the methazolamide. The maximum loading of methazolamide studied using UV-vis spectrophotometry was about 0.2% (w/w). The drug-loaded particles had a negative surface charge at about -30 mV while their mean particle diameter was estimated to be 256.4 nm. In vitro release studies demonstrated diffusion-controlled release of methazolamide from the CaP nanoparticles over a period of 4 h. In vivo studies indicated that the intraocular pressure (IOP)-lowering effect of the inorganic nanoparticle eye drops lasted for 18 h, which was significantly better than the effect of 1% brinzolamide eye drops (6 h). Physical stability studies indicated that the preparation was stable for 6 months at 40°C. These findings suggested that methazolamide bound to CaP nanoparticles might be useful in the local treatment of glaucoma.
- 公益社団法人 日本薬学会の論文
著者
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Chen Rui
Department of Pediatrics, Toyama Medical and Pharmaceutical University
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LI Rui
Department of Dental Materials, Nihon University School of Dentistry at Matsudo
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Rui Chen
Department Of Pediatrics Toyama Medical And Pharmaceutical University
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Chen Rui
Department Of Aeronautical And Automotive Engineering Loughborough University
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ZHANG Qing
Department of Nephrology, Yan Tai Yu Huang Ding Hospital, Qing Dao University School of Medicine
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QIAN Yong
Department of Pharmaceutics, Nanjing Medical University
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LIU Dongfei
Department of Pharmaceutics, Nanjing Medical University
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WANG Miao
Department of Pathology, Nanjing Medical University
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XU Qunwei
Department of Pharmaceutics, Nanjing Medical University
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Zhang Qing
Department Of Biochemistry Ii Nagoya University Graduate School Of Medicine
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Zhang Qing
Department Of Applied Chemistry Saga University
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Yong Qian
Department of Pharmaceutics, Nanjing Medical University
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Rui Li
Department of Pharmaceutics, Nanjing Medical University
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CHEN Rui
Department of Pharmaceutics, Nanjing Medical University
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LI Rui
Department of Pharmaceutics, Nanjing Medical University
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ZHANG Qing
Department of Pharmaceutics, Nanjing Medical University
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