Deguelin Represses Both the Expression of Nucleophosmin and some Nucleoporins : Nup88 and Nup214 in Jurkat Cells(Molecular and Cell Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Since the first report about cytoplasmic nucleophosmin (NPM) in acute myelogenous leukemia with a normal karyotype was announced, the shuttling activity of NPM and its proper subcellular localization have drawn many attentions. Mechanisms that regulate nucleocytoplasmic transport of proteins may provide novel opportunities for drug development. Here we show that, in Jurkat cells, strong fluorescence density of NPM prevails in the nucleus, while, some key nucleoporins: Nup88 and Nup214 localize mainly in the cytoplasm. Deguelin, a natural occurring rotenoid, presents powerful anti-leukemia effects through proliferation inhibition and apoptosis induction in Jurkat cells. Deguelin downregulates the expression of NPM, Nup88 and Nup214 in a dose-dependent manner and reverts the localization of Nup88 and Nup214 to nuclear rim. These results suggest that deguelin exhibit its strong anti-leukemia effects might through the regulation of some nucleoporins, thus influence the subsequent abnormal expressions or localizations of some key proteins involved in proliferation and/or apoptosis, such as: NPM.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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CHEN Yan
Department of Pediatrics, West China Second University Hospital, Sichuan University
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Cui Guohui
Institute Of Hematology Union Hospital Tongji Medical College Of Huazhong University Of Science And
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LI Rui
Department of Dental Materials, Nihon University School of Dentistry at Matsudo
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Wu Qing
Department of Occupational Health and Toxicology, Fudan University School of Public Health
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Li Rui
Institute Of Hematology Union Hospital Tongji Medical College Of Huazhong University Of Science And
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SHU Wenxiu
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and
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CUI Guohui
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and
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Wu Qing
Institute Of Hematology Union Hospital Tongji Medical College Of Huazhong University Of Science And
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Chen Yan
Institute Of Hematology Union Hospital Tongji Medical College Of Huazhong University Of Science And
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Chen Yan
The State Engineering Lab. Of Aids Vaccine Jilin Univ.
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Shu Wenxiu
Department Of Hematology Union Hospital Tongji Medical College Huazhong University Of Science And Te
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Chen Yan
Department Of Hematology Union Hospital Tongji Medical College Huazhong University Of Science And Te
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Chen Yan
Department Of Chemistry University Of Washington
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Li Rui
Department Of Chemical And Biological Science Japan Women's University
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Wu Qing
Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, PR China
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