Differential Impact of Atorvastatin vs Pravastatin on Progressive Insulin Resistance and Left Ventricular Diastolic Dysfunction in a Rat Model of Type II Diabetes
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概要
- 論文の詳細を見る
Background Controversy exists regarding the effects of statin therapy on progressive insulin resistance (IR) and its consequences, in the present study a rat model of spontaneously developing type II diabetes mellitus (DM) was used to examine the impact of atorvastatin (AS) vs pravastatin (PS). Methods and Results The Otsuka Long-Evans Tokushima Fatty rats were either untreated or treated with 100mg/kg per day of AS or PS from 6 weeks of age for 24 weeks. AS achieved much greater lipid lowering than PS. Serial oral glucose tolerance tests revealed new-onset diabetes was delayed by PS only. The untreated rats exhibited a progressive decrease in plasma adiponectin, increases in plasma leptin and tumor necrosis factor-α, and reduction of plasma nitric oxide (NO), which were limited more by PS than AS. PS, but not AS, enhanced adiponectin mRNA expression in white adipose tissue at 30 weeks. Cardiac endothelial NO synthase expression was upregulated, and overexpression of both transforming growth factor-β1 and monocyte chemoattractant protein-1 mRNA was limited more by PS than AS. Coronary perivascular fibrosis at 30 weeks was suppressed only by PS, which was accompanied by preserved left ventricular diastolic function assessed with Doppler echocardiography. Conclusions The moderate lipid lowering by PS, but not the intensive lipid lowering by AS, prevented new-onset DM and diastolic dysfunction in a rat model of IR, and this was associated with preferable adipocytokine profiles and cardiac redox states.
- 社団法人日本循環器学会の論文
- 2006-12-20
著者
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Kohno Masakazu
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University Medical School
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Kohno Masakazu
香川大学 医学部総合診療部
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CHEN Yan
Department of Pediatrics, West China Second University Hospital, Sichuan University
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Yoshikawa Junichi
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Yoshida Junji
Department of Thoracic Oncology, National Cancer Center Hospital East
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Kohno Masakazu
Department Of Cardiology Osaka Rosai Hospital
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Yoshikawa Junichi
Department Of Cardiorenal Cerebrovasucluar Medicine
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Yoshida Junji
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Zeng Yu
Urology Kagawa University School Of Medicine
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OHMORI Koji
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University
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Shinomiya Kaori
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University
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Shinomiya Kaori
Kadawa University Department of Clinical Laboratory
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Mizukawa Mizuki
Department of Cardiorenal Cerebrovascular Medicine, Kagawa University School of Medicine
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Zhang Ling
Cardiovascular Physiology, Kagawa University School of Medicine
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Kosaka Hiroaki
Cardiovascular Physiology, Kagawa University School of Medicine
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Chen Yan
Departments Of Cardiorenal Cerebrovascular Medicine
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Ohmori Koji
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Ohmori Koji
Second Department Of Internal Medicine Kagawa Medical University
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Ohmori Koji
Scond Department Of Internal Medicine Kagawa Medical University
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Chen Yan
Department Of Hematology Union Hospital Tongji Medical College Huazhong University Of Science And Te
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Kosaka Hiroaki
Department Of Cardiovascular Physiology Kagawa University Faculty Of Medicine
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Kosaka Hiroaki
Cardiovascular Physiology Faculty Of Medicine Kagawa University
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Mizukawa Mizuki
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Ohmori Koji
Second Department Of Internal Medicine Faculty Of Medicine Kagawa University
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Zhang Ling
Cardiovascular Physiology Kagawa University School Of Medicine
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Chen Yan
Department Of Chemistry University Of Washington
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KOHNO Masakazu
Department of Cardio Renal and Cerebro Vascular Medicine, Faculty of Medicine, Kagawa University
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Ohmori Koji
Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Japan
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