A Resected Case of Pulmonary Large Cell Neuroendocrine Carcinoma Showing Aggressive Progression
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概要
- 論文の詳細を見る
Background. In 1991, Travis et al. proposed a new category of large cell neuroendocrine carcinoma (LCNEC). Some investigators reported poor prognosis of LCNEC patients, with 5-year survival rates similar to small cell carcinoma. We report a case of LCNEC with aggressive progression after complete resection. Case. A 71-year-old man underwent left pneumonectomy and lymph node dissection for lung cancer on June 13, 2002. No finding suggested distant metastasis. The pathological diagnosis was large cell neuroendocrine carcinoma, T2N1M0, stage IIB. Two months after surgery, he presented with lumbago. Bone scintigram and magnetic resonance imaging revealed bone metastasis to the right sacroiliac joint. A brain metastasis was also detected by computed tomography. He received 30-Gy brain irradiation and 30-Gy bone radiotherapy to relieve the pain. Although the radiotherapy alleviated the pain, the brain and sacroiliac joint metastases did not shrink. The patient died of recurrent lung cancer 99 days after the surgical resection. Conclusion. We reported an aggressive progression case of pulmonary LCNEC. Prognosis and treatment efficacy in LCNEC patients remain controversial, and further investigation is needed.
- 日本肺癌学会の論文
- 2005-10-20
著者
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Nishiwaki Yutaka
国立がんセンター東病院 呼吸器外科
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Nishiwaki Y
Department Of Thoracic Oncology National Cancer Center Hospital East
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Shiono Satoshi
Department of Thoracic Oncology, National Cancer Center Hospital East
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Nagai Kanji
Department of Thoracic Oncology, National Cancer Center Hospital East
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Yoshida Junji
Department of Thoracic Oncology, National Cancer Center Hospital East
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Nishimura Mitsuyo
Department of Thoracic Oncology, National Cancer Center Hospital East
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Ishii Genichiro
Pathology Division, National Cancer Center Research Institute East
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Nishiwaki Yutaka
Department of Thoracic Oncology, National Cancer Center Hospital East
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Nagai K
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai Kanji
国立がんセンター東病院 呼吸器外科
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Yoshida Junji
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Yoshida Junji
国立がんセンター東病院 呼吸器外科
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Yoshida J
Department Of Thoracic Oncology National Cancer Center Hospital East
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Shiono Satoshi
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai Kanji
Divisions Of Thoracic Oncology National Cancer Center Research Institute East
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Ishii Genichiro
Pathology Division Research Center For Innovative Oncology National Cancer Center Hospital East
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Ishii Genichiro
Pathology Division Research Center For Innovative Oncology Hospital East
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Ishii Genichiro
Pathology Division National Cancer Center Research Center For Innovative Oncology
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Nishiwaki Yutaka
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai Kanji
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nishimura Mitsuyo
Thoracic Oncology Division National Cancer Center Hospital East
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Nakaya Y
National Cancer Center Res. Inst. Kashiwa
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Nagai Kanji
Department Of Molecular Design And Engineering Graduate School Of Engineering Nagoya University
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