Two Lung Adenocarcinomas in the Same Lobe : Multiple Primaries or Intrapulmonary Metastasis?
スポンサーリンク
概要
- 論文の詳細を見る
Abnormal nodules were found in the left lung of a 52-year-old woman in segments 6 and 10 on a chest CT. These nodules showed no changes for 18 months, and we discontinued follow-up. Almost 5 years later, an abnormal shadow was found in her left lower lung field on a medical check-up chest X-ray. Chest CT revealed that the left segments 6 and 10 nodules had grown. We diagnosed these lesions as synchronous double primary lung cancers in the same lobe based on the disease history and performed a left lower lobectomy and lymph node dissection. Pathological examination of both tumors revealed adenocarcinoma of a mixed subtype with papillary and bronchioloalveolar carcinoma. Epidermal growth factor receptor gene mutations were examined, and the 2 lesions shared an L858R mutation. Although we expected EGFR gene mutation analysis would help us distinguish the 2 lesions from each other, it was of little help. Disease history can be more important in evaluating multiple pulmonary cancers.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
- 2011-12-01
著者
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Nishimura Mitsuyo
Department of Thoracic Oncology, National Cancer Center Hospital East
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Hishida Tomoyuki
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai K
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai Kanji
国立がんセンター東病院 呼吸器外科
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Yoshida Junji
Department Of Cardiorenal Cerebrovascular Medicine Kagawa University Faculty Of Medicine
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Yoshida Junji
国立がんセンター東病院 呼吸器外科
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Yoshida J
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nagai Kanji
Divisions Of Thoracic Oncology National Cancer Center Research Institute East
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Ishii Genichiro
Pathology Division Research Center For Innovative Oncology National Cancer Center Hospital East
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Ishii Genichiro
Pathology Division National Cancer Center Research Center For Innovative Oncology
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Nagai Kanji
Department Of Thoracic Oncology National Cancer Center Hospital East
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Nishimura Mitsuyo
Thoracic Oncology Division National Cancer Center Hospital East
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Yoshimoto Kentaro
Department Of Thoracic Surgery Graduate School Of Medical Sciences Kumamoto University
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Yoshimoto Kentaro
Department Of Thoracic Oncolog National Cancer Center Hospital East
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Nagai Kanji
Department Of Molecular Design And Engineering Graduate School Of Engineering Nagoya University
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