Uterus transplantation and ovarian cryopreservation for fertility reconstruction in female genital cancer patients : Collaboration: Reconstructive surgery ∗ Transplantation surgery
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概要
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Recently, a therapy aimed to preserve fertility has been developed for patients with female genital cancer. However, carcinoma excision needs to be performed for cases of advanced disease stage at the expense of fertility. We have been conducting an ovarian cryopreservation study and uterus transplant study under immunosuppression in an attempt to reconstruct fertility in patients with a radical hysterectomy due to advanced disease. It may seem to be too early to expect clinical application of a uterus transplant study at this stage of development because many ethical and legal problems remain to be solved. However, we believe it is very important to raise the possibility for those patients undergoing radical hysterectomy to have babies by cryopreserving a part of the removed ovary so that IVM-IVF (in vitro maturation-in vitro fertilization) technique may be adopted in the future when the technology advances to the point of achieving a mature ovum from an oogonium. We aim at safe fertility reconstruction in patients who had a hysterectomy due to uterine cancer by establishing a new uterus transplant based on an effort to integrate Super-Microsurgery, an advanced vascular anastomosis technique in the plastic surgery and reconstructive surgery field, and organ transplantation under immune tolerance, an advance in the transplantation surgery field. Considering studies of surrogate mothers and uterus transplants, cryopreservation of part of removed ovarian tissue (not used for pathological diagnosis) in patients with female genital cancer can be very important. We present the following report on the development of uterus transplant experiment model of pigs.
著者
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Halim Ahmad
Reconstructive Sciences Unit, School of Medical Sciences, University Sains Malaysia
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Nakagawa Takashi
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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Noguchi Shuhei
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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Mihara Makoto
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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Nakagawa Takashi
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Halim Ahmad
Reconstructive Sciences Unit School Of Medical Sciences Universiti Sains Malaysia
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Mihara Makoto
Department of plastic and reconstructive surgery, The University of Tokyo Hospital.
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