The generation of human induced pluripotent stem (iPS) cells from liver progenitor cells by only small molecules and the risk for malignant transformations of the cells : Regenerative medicine, Chemical Biology, Oncology *
スポンサーリンク
概要
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Induced pluripotent stem (iPS) cells have been generated from human somatic cells by overexpression of defined factors. Human iPS cells are expected as research tools for drug development and regenerative medicine. However, though clinical applications of human iPS cells require avoiding viral transgenes, the reprogramming of human cells with only small molecules has yet to be reported. Therefore, here we show the reprogramming of human liver progenitor cells with only two small molecules. We designated the human iPS cells as Chemicals-human induced pluripotent stem (ChiPS) cells. Furthermore, we have found that the induction of p21 is necessary to avoid malignant transformations of human iPS cells including ChiPS cells. In conclusion, our findings in the present study would be helpful for sick children with severe diseases in the near future.
著者
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Mihara Makoto
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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Sato Chifumi
Department Of Analytical Health Science Graduate School Of Health Sciences Tokyo Medical And Dental
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Moriguchi Hisashi
Department of plastic and reconstructive surgery, The University of Tokyo Hospital.
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Chung Raymond
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School.
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Sato Chifumi
Department of Analytical Sciences, Tokyo Medical and Dental University.
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